Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 14/20 | 0.62 |
| ▸ | TACR2 | P21452 | 12/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5422562 | 0.95 | TACR3 (0.67) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL5945439 | 0.85 | TRPV4 (0.60) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL5425466 | 0.83 | TACR3 (0.55) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6957829 | 0.83 | TACR3 (0.54) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL5417753 | 0.83 | DHODH (0.61) | TACR3TACR2OPRM1KCNH2DHODH | |
| SCHEMBL5427056 | 0.83 | DHODH (0.55) | TACR3TACR2OPRM1KCNH2DHODH | |
| SCHEMBL6853012 | 0.82 | TACR3 (0.64) | TACR3TACR2OPRM1KCNH2PDE10A | |
| Hydrochloric Acid SCHEMBL6958335 | 0.82 | TACR3 (0.53) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL5457349 | 0.82 | TACR3 (0.52) | TACR3TACR2OPRM1KCNH2LMNA | |
| SCHEMBL6848956 | 0.81 | TACR2 (0.61) | TACR3TACR2OPRM1KCNH2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377567-B1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE SPA (IT) | 2005-12-21 | — | — | EP | claimed |
| EP-1377567-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002083663-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE S.P.A. (IT) | 2002-10-24 | — | — | WO | disclosed |