Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.66 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204073 | 0.94 | MMP13 (0.68) | MMP13CXCR1SCD5 | |
| SCHEMBL6204266 | 0.93 | MMP13 (0.73) | MMP13CXCR1 | |
| SCHEMBL6202352 | 0.93 | MMP13 (0.73) | MMP13CXCR1 | |
| SCHEMBL6205587 | 0.87 | MMP13 (0.69) | MMP13 | |
| SCHEMBL6203135 | 0.87 | MMP13 (0.70) | MMP13 | |
| SCHEMBL6202336 | 0.87 | MMP13 (0.72) | MMP13 | |
| SCHEMBL6202145 | 0.86 | MMP13 (0.60) | MMP13CXCR1 | |
| SCHEMBL6203616 | 0.86 | MMP13 (0.71) | MMP13 | |
| SCHEMBL6203917 | 0.86 | MMP13 (0.65) | MMP13 | |
| SCHEMBL6204843 | 0.85 | MMP13 (0.73) | MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501834-B1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1501834-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091259-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |