Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
| ▸ | CPA1 | P15085 | 7/20 | 0.57 |
| ▸ | CPA3 | P15088 | 3/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.57 |
| ▸ | CPB1 | P15086 | 1/20 | 0.57 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.57 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127819 | 0.83 | MDM2 (0.66) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL11713368 | 0.83 | MDM2 (1.00) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL8733905 | 0.82 | MDM2 (0.54) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL8733908 | 0.82 | MDM2 (0.54) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL7037701 | 0.81 | MDM2 (0.88) | MDM2CYP1A2CPA1CPA3FOLH1 | |
| SCHEMBL5609576 | 0.81 | MDM2 (0.68) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL3355858 | 0.81 | MDM2 (0.88) | MDM2CYP1A2CPA1CPA3FOLH1 | |
| SCHEMBL5610140 | 0.81 | MDM2 (0.68) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL26065 | 0.81 | MDM2 (0.68) | MDM2CYP1A2MMP2MMP9MMP12 | |
| SCHEMBL11772434 | 0.80 | MME (0.51) | MDM2CYP1A2MMP2MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |