Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200505 | 1.00 | HTR6 (0.51) | HTR6GAANOX1MEN1CYP2D6 | |
| SCHEMBL6201833 | 1.00 | HTR6 (0.51) | HTR6GAANOX1MEN1CYP2D6 | |
| SCHEMBL6224659 | 1.00 | HTR6 (0.51) | HTR6GAANOX1MEN1CYP2D6 | |
| SCHEMBL6218260 | 1.00 | HTR6 (0.51) | HTR6GAANOX1MEN1CYP2D6 | |
| SCHEMBL6198477 | 1.00 | HTR6 (0.51) | HTR6GAANOX1MEN1CYP2D6 | |
| SCHEMBL6202313 | 0.89 | HTR6 (0.54) | HTR6DRD3HTR2C | |
| SCHEMBL6220923 | 0.89 | HTR6 (0.54) | HTR6DRD3HTR2C | |
| SCHEMBL6198846 | 0.89 | HTR6 (0.54) | HTR6DRD3HTR2C | |
| SCHEMBL6201008 | 0.89 | HTR6 (0.54) | HTR6DRD3HTR2C | |
| SCHEMBL6202015 | 0.89 | HTR6 (0.54) | HTR6DRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351961-B1 | SUBSTITUTED INDOLINES AS 5-HT RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2005-07-27 | — | — | EP | claimed |