Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 12/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201006 | 0.92 | AURKA (0.66) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6202620 | 0.88 | AURKA (0.60) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL6200951 | 0.87 | AURKA (0.59) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200494 | 0.82 | AURKA (0.71) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200264 | 0.82 | AURKA (0.64) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200961 | 0.79 | AURKA (0.71) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6201508 | 0.78 | AURKA (0.59) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200887 | 0.77 | AURKA (0.57) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL6204384 | 0.77 | AURKA (0.44) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL6203308 | 0.76 | AURKA (0.55) | AURKAALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-B1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-03-16 | — | — | EP | disclosed |
| EP-1425283-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003018589-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-03-06 | — | — | WO | disclosed |