Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028662 | 0.91 | CCR3 (0.58) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4025910 | 0.91 | CCR3 (0.51) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4028498 | 0.89 | CCR3 (0.66) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL5776085 | 0.89 | CCR3 (0.68) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL7086085 | 0.88 | CCR3 (0.57) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4021803 | 0.88 | CCR3 (0.59) | CCR3DRD4SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL5832184 | 0.88 | CCR3 (0.56) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4024938 | 0.87 | CCR3 (0.62) | CCR3DRD4SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL5832441 | 0.86 | CCR3 (0.60) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4024792 | 0.86 | CCR3 (0.57) | CCR3DRD4SIGMAR1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492537-A1 | MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082294-A1 | MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |