Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028498 | 0.91 | CCR3 (0.66) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4021803 | 0.91 | CCR3 (0.59) | CCR3DRD4SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL4156918 | 0.91 | CCR3 (0.61) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4024938 | 0.89 | CCR3 (0.62) | CCR3DRD4SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL4024792 | 0.89 | CCR3 (0.57) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL5832441 | 0.89 | CCR3 (0.60) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL6202605 | 0.88 | CCR3 (0.55) | CCR3DRD4SIGMAR1NPC1MEN1 | |
| SCHEMBL6202331 | 0.88 | CCR3 (0.55) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL4027381 | 0.88 | CCR3 (0.59) | CCR3DRD4SIGMAR1MEN1LMNA | |
| SCHEMBL5618491 | 0.88 | CCR3 (0.71) | CCR3DRD4SIGMAR1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324990-A1 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002026722-A1 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |