Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206390 | 0.78 | AOC3 (0.44) | ALDH1A1HPGDLMNAMAPTKDM4E | |
| SCHEMBL6205148 | 0.78 | ADRB2 (0.44) | CYP2A6HPGDLMNAMAPTMAPK1 | |
| SCHEMBL6205817 | 0.78 | CA1 (0.52) | CYP1A2ALDH1A1CYP2A6MEN1MAPK1 | |
| SCHEMBL83160 | 0.77 | KMT2A (0.46) | ALDH1A1HPGDKMT2A | |
| SCHEMBL6502 | 0.77 | CYP2A6 (0.42) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 | |
| SCHEMBL16177721 | 0.75 | CYP2A6 (0.40) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 | |
| SCHEMBL3322412 | 0.75 | CYP2A6 (0.40) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 | |
| SCHEMBL31353465 | 0.75 | CYP2A6 (0.40) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 | |
| SCHEMBL6202340 | 0.73 | CYP1A2 (0.42) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 | |
| SCHEMBL10997001 | 0.73 | CYP2A6 (0.38) | CYP1A2ALDH1A1CYP2A6HPGDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |