Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.53 |
| ▸ | HRH2 | P25021 | 8/20 | 0.53 |
| ▸ | HRH1 | P35367 | 8/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2968099 | 0.86 | KCNA5 (0.54) | KCNA5HRH3HRH2HRH1MMP2 | |
| SCHEMBL6094334 | 0.85 | HRH2 (0.61) | KCNA5HRH3HRH2HRH1 | |
| Oxalic Acid SCHEMBL4495391 | 0.84 | HRH3 (0.56) | KCNA5HRH3HRH2HRH1KDM4E | |
| SCHEMBL6095505 | 0.83 | GPR119 (0.51) | KCNA5HRH3HRH2HRH1 | |
| SCHEMBL6199791 | 0.83 | USP30 (0.43) | KCNA5HRH3HRH2HRH1KDM4E | |
| SCHEMBL6096450 | 0.83 | HRH2 (0.53) | KCNA5HRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL6094006 | 0.83 | HRH2 (0.49) | KCNA5HRH3HRH2HRH1 | |
| SCHEMBL6093755 | 0.83 | HRH3 (0.49) | KCNA5HRH3HRH2HRH1 | |
| SCHEMBL6095474 | 0.83 | HRH1 (0.50) | KCNA5HRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL6094934 | 0.82 | KCNA5 (0.47) | KCNA5HRH3HRH2HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360187-B1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | disclosed |