SCHEMBL6202486

SCHEMBL6202486

O=C(Cc1cccc(C(F)(F)F)c1)NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 1/20 0.55
SIGMAR1 Q99720 4/20 0.51
DRD4 P21917 2/20 0.47
KCNH2 Q12809 1/20 0.47
CACNA1I Q9P0X4 1/20 0.47
MCHR1 Q99705 1/20 0.46
S1PR1 P21453 2/20 0.46
S1PR5 Q9H228 2/20 0.46
LMNA P02545 1/20 0.46
ALDH1A1 P00352 1/20 0.45
CCR2 P41597 1/20 0.44
GRK5 P34947 1/20 0.44
CDK8 P49336 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4024728 0.92 CCR3 (0.57) CCR3SIGMAR1DRD4KCNH2MCHR1
SCHEMBL4021903 0.91 CCR3 (0.58) CCR3SIGMAR1DRD4KCNH2MCHR1
SCHEMBL4028498 0.89 CCR3 (0.66) CCR3SIGMAR1DRD4KCNH2S1PR5
SCHEMBL5773270 0.89 CCR3 (0.68) CCR3SIGMAR1DRD4KCNH2CACNA1I
SCHEMBL4024792 0.88 CCR3 (0.57) CCR3SIGMAR1DRD4KCNH2LMNA
SCHEMBL4021803 0.88 CCR3 (0.59) CCR3SIGMAR1DRD4
SCHEMBL4024938 0.87 CCR3 (0.62) CCR3SIGMAR1DRD4ALDH1A1
SCHEMBL5832441 0.86 CCR3 (0.60) CCR3SIGMAR1DRD4KCNH2LMNA
SCHEMBL7086085 0.86 CCR3 (0.57) CCR3SIGMAR1DRD4KCNH2LMNA
SCHEMBL4027381 0.86 CCR3 (0.59) CCR3SIGMAR1DRD4KCNH2S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1492537-A1 MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES GLAXO GROUP LIMITED (GB) 2005-01-05 EP disclosed
WO-2003082294-A1 MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES GLAXO GROUP LIMITED (GB) 2003-10-09 WO disclosed