Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL22588019 | 0.93 | DCUN1D1 (0.53) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2791615 | 0.93 | HTR2A (0.51) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL2791610 | 0.92 | HTR2A (0.50) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL803880 | 0.88 | CCR5 (0.54) | HTR2ASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL30802298 | 0.87 | SLC6A2 (0.45) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL5232869 | 0.87 | CCR5 (0.53) | HTR2ASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL27584286 | 0.87 | DCUN1D1 (0.48) | DCUN1D1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL16095918 | 0.87 | HTR2A (0.45) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7131705 | 0.86 | SLC6A4 (0.53) | HTR2ASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL6039277 | 0.86 | HTR2A (0.46) | HTR2ADCUN1D1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492790-A1 | IMIDAZO FUSED COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082871-A1 | IMIDAZO FUSED COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-09 | — | — | WO | disclosed |
| EP-1315726-A1 | 7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002018380-A1 | 7-OXO PYRIDOPYRIMIDINES AS INHIBITORS OF A CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | WO | disclosed |