Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909215 | 1.00 | L3MBTL3 (0.67) | L3MBTL3RECQLL3MBTL1HRH3GAA | |
| SCHEMBL5165696 | 0.93 | L3MBTL3 (0.62) | L3MBTL3RECQLL3MBTL1HRH3JAK2 | |
| SCHEMBL10293598 | 0.86 | L3MBTL3 (0.69) | L3MBTL3L3MBTL1HRH3PDK2KDM4E | |
| SCHEMBL10293555 | 0.86 | L3MBTL3 (0.69) | L3MBTL3L3MBTL1HRH3PDK2KDM4E | |
| SCHEMBL24185235 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2JAK2 | |
| SCHEMBL12237837 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2 | |
| SCHEMBL12237840 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2 | |
| SCHEMBL2887400 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2JAK2 | |
| SCHEMBL10195734 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2 | |
| SCHEMBL24185230 | 0.85 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HRH3PDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |