Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.58 |
| ▸ | TP53 | P04637 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086345 | 0.96 | MAPT (0.54) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6085204 | 0.94 | PTPN1 (0.61) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6200297 | 0.93 | PTPN1 (0.63) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6084084 | 0.90 | ALDH1A1 (0.52) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6084199 | 0.89 | PTPN2 (0.54) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6085198 | 0.89 | PTPN1 (0.61) | MAPTLMNAPTPN2PTPN1PTPN5 | |
| SCHEMBL6084988 | 0.88 | ALDH1A1 (0.53) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6084209 | 0.85 | PTPN2 (0.49) | MAPTTP53LMNAPOLBPTPN2 | |
| SCHEMBL6201863 | 0.83 | PTPN1 (0.74) | MAPTTP53LMNAPTPN2PTPN1 | |
| SCHEMBL6086978 | 0.82 | ALDH1A1 (0.49) | MAPTTP53LMNAPOLBPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |