Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | UBE2N | P61088 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1790077 | 1.00 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL1787179 | 0.88 | TNK2 (0.58) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL6848486 | 0.88 | TNK2 (0.58) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL20492595 | 0.83 | SMN1; SMN2 (0.43) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL6200319 | 0.83 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL735560 | 0.79 | TNK2 (0.68) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL22320612 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL22320704 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL6202459 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EUBE2NTSHR | |
| SCHEMBL1786166 | 0.76 | TEK (0.71) | ALDH1A1HPGDKDM4EUBE2NTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-B1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-03-16 | — | — | EP | disclosed |
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | DPYD, TPMT, TYMP | ALDH1A1 176/4885HPGD 389/4885KDM4E 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.