Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9066674 | 0.82 | ATM (0.74) | SMN1; SMN2NPC1ATML3MBTL1TSHR | |
| SCHEMBL1983010 | 0.82 | NPC1 (0.63) | SMN1; SMN2NPC1RAB9AEPHX2GAA | |
| SCHEMBL7968837 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AEPHX2GAA | |
| SCHEMBL1924138 | 0.79 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AEPHX2GAA | |
| SCHEMBL31530566 | 0.79 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9AEPHX2GAA | |
| SCHEMBL8431654 | 0.79 | L3MBTL1 (0.74) | SMN1; SMN2NPC1ATML3MBTL1GAA | |
| SCHEMBL16616451 | 0.78 | ATM (0.68) | SMN1; SMN2ATML3MBTL1TSHRMAPT | |
| SCHEMBL1986644 | 0.77 | NPC1 (0.56) | SMN1; SMN2NPC1RAB9AEPHX2GAA | |
| SCHEMBL28114650 | 0.76 | ATM (0.66) | SMN1; SMN2NPC1ATML3MBTL1GAA | |
| SCHEMBL12158645 | 0.76 | ATM (0.66) | SMN1; SMN2NPC1ATML3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |