Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636659 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL4034560 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL4027876 | 0.71 | NR1H2 (0.54) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL5636903 | 0.64 | ESR1 (0.39) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL4030745 | 0.64 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL4034521 | 0.64 | KDM4E (0.42) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL2451498 | 0.63 | HPGD (0.54) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL5634746 | 0.62 | SMPD1 (0.41) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4032536 | 0.62 | ESR1 (0.50) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL3938987 | 0.61 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-A1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | Wyeth (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004031159-A1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH (US) | 2004-04-15 | — | — | WO | disclosed |