Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.50 |
| ▸ | PPARG | P37231 | 14/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31123806 | 1.00 | PPARA (0.50) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL4011585 | 0.76 | PPARA (0.61) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL6920085 | 0.75 | PPARA (0.52) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL14588770 | 0.75 | PPARA (0.39) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL8262762 | 0.71 | PPARA (0.45) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL20222864 | 0.70 | PPARA (0.55) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL4019204 | 0.70 | PPARA (0.52) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL18644967 | 0.69 | PPARA (0.67) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL7167912 | 0.68 | PPARA (0.72) | PPARAPPARGNR1H3NR1H2PPARD | |
| SCHEMBL9910141 | 0.68 | PPARA (0.53) | PPARAPPARGNR1H3NR1H2PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366012-A4 | 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS | MERCK & CO INC (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1366012-A2 | 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS | Merck & Co., Inc. (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002064094-A2 | 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |