Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.53 |
| ▸ | PPARG | P37231 | 12/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 12/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.52 |
| ▸ | PPARD | Q03181 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400248 | 0.84 | PPARA (0.55) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL20222864 | 0.84 | PPARA (0.55) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL24648544 | 0.82 | PPARG (0.61) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL12798638 | 0.82 | PPARG (0.53) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL6098587 | 0.78 | NR1H2 (0.52) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL6099414 | 0.77 | NR1H3 (0.69) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL1400270 | 0.77 | NR1H3 (0.66) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL6168918 | 0.76 | NR1H3 (0.68) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL1401077 | 0.76 | NR1H3 (0.71) | PPARAPPARGNR1H2NR1H3PPARD | |
| SCHEMBL6100664 | 0.76 | PPARG (0.60) | PPARAPPARGNR1H2NR1H3PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140370011-A1 | METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140086910-A1 | METHODS OF TREATING OR PREVENTING ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20120141483-A1 | METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. | 2012-06-07 | — | — | US | disclosed |
| WO-2012074980-A2 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISORDERS AND LIVER DISORDERS USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| EP-1578715-B1 | INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION | BAYER PHARMACEUTICALS CORP (US) | 2011-03-02 | — | — | EP | disclosed |
| US-7714004-B2 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation | BAYER PHARMACEUTICALS CORPORATION (US) | 2010-05-11 | — | — | US | disclosed |
| US-7449478-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140086910-A1 | METHODS OF TREATING OR PREVENTING ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | ACHE, CHAT, APP | PPARA 368/4885PPARG 684/4885NR1H2 357/4885 |
| US-20140370011-A1 | METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES | CHAT, ACHE, AANAT | PPARA 507/4885PPARG 596/4885NR1H2 632/4885 |
| US-20120141483-A1 | METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | APP, MAPT, TNF | PPARA 56/4885PPARG 81/4885NR1H2 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.