Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | STK3 | Q13188 | 4/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.52 |
| ▸ | STK4 | Q13043 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202985 | 0.80 | AURKA (0.87) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6199702 | 0.80 | AURKA (0.78) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6202155 | 0.74 | AURKA (0.73) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6204036 | 0.73 | AURKA (0.69) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200494 | 0.73 | AURKA (0.71) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200961 | 0.72 | AURKA (0.71) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6200264 | 0.72 | AURKA (0.64) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL12789817 | 0.69 | ALDH1A1 (0.75) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6201006 | 0.69 | AURKA (0.66) | AURKAALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL31301556 | 0.69 | LRRK2 (1.00) | AURKASTK3LRRK2STK4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-B1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-03-16 | — | — | EP | disclosed |
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-12-23 | — | — | US | disclosed |
| EP-1425283-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003018589-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | DPYD, TPMT, TYMP | AURKA 795/4885ALDH1A1 176/4885HPGD 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.