Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | OXTR | P30559 | 1/20 | 0.53 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582617 | 0.86 | GSK3B (0.59) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL6847468 | 0.77 | GSK3B (0.53) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL6847853 | 0.77 | GSK3B (0.51) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL15988673 | 0.77 | GSK3B (0.73) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL6847082 | 0.76 | KMT2A (0.55) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL193501 | 0.75 | GSK3B (1.00) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL10844749 | 0.75 | GSK3B (0.70) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL4927332 | 0.75 | HPGD (0.65) | KMT2AMEN1DAOMAPTNPSR1 | |
| Bromobenzene SCHEMBL5171768 | 0.75 | L3MBTL1 (0.54) | GSK3BKMT2AMEN1DAOMAPT | |
| SCHEMBL6847547 | 0.75 | ACKR3 (0.65) | GSK3BKMT2AMEN1DAOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |