Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR5A | P47898 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | HTR1E | P28566 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7227737 | 0.99 | PARP1 (0.46) | PARP1FLT3HTR1AHTR1DHTR7 | |
| SCHEMBL6203062 | 0.86 | PARP1 (0.46) | PARP1FLT3HTR1AHTR1DHTR7 | |
| Hydrochloric Acid SCHEMBL7235812 | 0.85 | PARP1 (0.45) | PARP1FLT3HTR1AHTR1DHTR7 | |
| SCHEMBL6202601 | 0.81 | KDM4E (0.47) | PARP1FLT3TNKSKDM4EALDH1A1 | |
| SCHEMBL6498712 | 0.80 | MAOA (0.52) | MAOA | |
| Hydrochloric Acid SCHEMBL7236341 | 0.80 | KDM4E (0.46) | PARP1FLT3TNKSKDM4EALDH1A1 | |
| SCHEMBL6197999 | 0.80 | TOP2A (0.54) | PARP1HTR1AHTR1DHTR7HTR5A | |
| Hydrochloric Acid SCHEMBL7236484 | 0.79 | TOP2A (0.53) | PARP1HTR1AHTR1DHTR7HTR5A | |
| Hydrochloric Acid SCHEMBL7226811 | 0.77 | TOP1 (0.44) | PARP1HTR1AHTR1DHTR7HTR5A | |
| Hydrochloric Acid SCHEMBL7226816 | 0.77 | TOP1 (0.44) | PARP1HTR1AHTR1DHTR7HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |