Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203471 | 0.84 | CCNB2 (0.46) | SMN1; SMN2TSHRHSD17B10TP53CCNB2 | |
| SCHEMBL4911838 | 0.83 | TSHR (0.66) | SMN1; SMN2TSHRHSD17B10TP53LMNA | |
| SCHEMBL30410663 | 0.83 | TSHR (0.66) | SMN1; SMN2TSHRHSD17B10TP53LMNA | |
| SCHEMBL30320075 | 0.78 | TSHR (0.60) | SMN1; SMN2TSHRHSD17B10TP53LMNA | |
| SCHEMBL3444371 | 0.77 | CDK2 (0.36) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL25173744 | 0.77 | SMN1; SMN2 (0.70) | SMN1; SMN2TSHRHSD17B10TP53EGFR | |
| SCHEMBL3445020 | 0.77 | SYK (0.35) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL16087271 | 0.76 | TSHR (0.66) | SMN1; SMN2TSHRHSD17B10TP53LMNA | |
| SCHEMBL16087109 | 0.76 | TSHR (0.66) | SMN1; SMN2TSHRHSD17B10TP53LMNA | |
| SCHEMBL4911828 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRHSD17B10TP53CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |