Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203475 | 0.84 | SMN1; SMN2 (0.45) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL4911828 | 0.82 | SMN1; SMN2 (0.45) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL3445017 | 0.80 | SYK (0.36) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL3444368 | 0.79 | CDK2 (0.41) | CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL6202539 | 0.77 | HDAC3 (0.41) | CCNB2CDK1CCNB1CCNB3EGFR | |
| SCHEMBL3444387 | 0.77 | CDK2 (0.49) | CDK1CCNB1 | |
| SCHEMBL3445342 | 0.76 | CDK1 (0.44) | CCNB2CDK1CCNB1CCNB3AURKA | |
| SCHEMBL3445669 | 0.76 | CDK2 (0.49) | CCNB2CDK1CCNB1CCNB3MAPK1 | |
| SCHEMBL3444743 | 0.76 | CDK2 (0.49) | CDK1CCNB1 | |
| SCHEMBL6205408 | 0.76 | PRUNE1 (0.35) | CCNB2CDK1CCNB1CCNB3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |