Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559138 | 0.88 | KMT2A (0.48) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL11563987 | 0.86 | CYP19A1 (0.47) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL6223181 | 0.86 | CYP19A1 (0.47) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL6227295 | 0.79 | CYP19A1 (0.51) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL11561273 | 0.79 | HSP90AA1 (0.44) | CYP19A1CYP3A4KMT2AHSP90AA1CYP26A1 | |
| SCHEMBL11563115 | 0.78 | CYP19A1 (0.50) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL11396775 | 0.77 | CYP3A4 (0.44) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL11561868 | 0.76 | KMT2A (0.49) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL9876679 | 0.76 | KMT2A (0.46) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA | |
| SCHEMBL11378731 | 0.76 | CYP3A4 (0.57) | CYP19A1CYP3A4KMT2AHSP90AA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |