Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | AURKA | O14965 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12789817 | 0.93 | ALDH1A1 (0.75) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6202459 | 0.90 | ALDH1A1 (0.53) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6201850 | 0.90 | ALDH1A1 (0.53) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6203768 | 0.89 | ALDH1A1 (0.66) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6202165 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6198425 | 0.88 | AURKA (0.52) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6202746 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6199583 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6204604 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDTSHRHSD17B10AURKA | |
| SCHEMBL6200494 | 0.78 | AURKA (0.71) | ALDH1A1HPGDTSHRHSD17B10AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-B1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-03-16 | — | — | EP | disclosed |
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259888-A1 | Novel 4-aminofuropyrimidines and the use thereof | DPYD, TPMT, TYMP | ALDH1A1 176/4885HPGD 389/4885TSHR 4809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.