Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7227956 | 0.99 | PARP1 (0.52) | PARP1TLR8TLR7ACHEESR1 | |
| SCHEMBL6203624 | 0.99 | TLR8 (0.53) | PARP1TLR8TLR7ACHEESR1 | |
| Hydrochloric Acid SCHEMBL7226820 | 0.98 | TLR8 (0.52) | PARP1TLR8TLR7ACHEESR1 | |
| SCHEMBL7234037 | 0.82 | TLR8 (0.48) | PARP1TLR8TLR7ACHEHRH3 | |
| SCHEMBL7234034 | 0.82 | TLR8 (0.48) | PARP1TLR8TLR7ACHEHRH3 | |
| SCHEMBL6203062 | 0.81 | PARP1 (0.46) | PARP1ESR1HRH3FLT3DRD2 | |
| Hydrochloric Acid SCHEMBL7235812 | 0.80 | PARP1 (0.45) | PARP1ESR1HRH3FLT3DRD2 | |
| SCHEMBL6203750 | 0.79 | ALDH1A1 (0.50) | KDR | |
| SCHEMBL6202045 | 0.79 | ESR1 (0.55) | ACHEESR1HRH3MAOBKDR | |
| Hydrochloric Acid SCHEMBL7234662 | 0.78 | ABCG2 (0.49) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |