Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PRKX | P51817 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496204 | 1.00 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6496213 | 1.00 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6496219 | 1.00 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL31231397 | 1.00 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6495821 | 0.93 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6204205 | 0.93 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6495817 | 0.93 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6495813 | 0.93 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6499384 | 0.91 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 | |
| SCHEMBL6203718 | 0.91 | ROCK1 (0.43) | ROCK2ROCK1CYP3A4CYP2C9PRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | claimed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | claimed |
| WO-2021113757-A1 | USE OF A KV7 POTASSIUM CHANNEL OPENER FOR TREATING PAIN | XENON PHARMACEUTICALS INC. (CA) | 2021-06-10 | — | — | WO | disclosed |
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |