Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183539 | 0.93 | GSK3B (0.41) | GSK3BCCNT1CDK9EIF2AK2MAPK10 | |
| SCHEMBL6105305 | 0.86 | EIF2AK2 (0.51) | GSK3BEIF2AK2MAPK10CDK5 | |
| SCHEMBL6106606 | 0.85 | EIF2AK2 (0.50) | GSK3BEIF2AK2MAPK10CDK5 | |
| SCHEMBL6106995 | 0.85 | EIF2AK2 (0.50) | GSK3BEIF2AK2MAPK10CDK5 | |
| SCHEMBL6338970 | 0.83 | CDK5 (0.59) | GSK3BEIF2AK2CDK5MEN1KMT2A | |
| SCHEMBL6108267 | 0.82 | GSK3B (0.51) | GSK3BCCNT1CDK9EIF2AK2MAPK10 | |
| SCHEMBL6106260 | 0.80 | GSK3B (0.49) | GSK3BEIF2AK2MAPK10CDK5 | |
| SCHEMBL6069055 | 0.79 | GSK3B (0.55) | GSK3BCDK5MEN1KMT2ANPC1 | |
| SCHEMBL6106090 | 0.78 | GSK3B (0.44) | GSK3BEIF2AK2MAPK10CDK5 | |
| SCHEMBL6184859 | 0.78 | GSK3B (0.53) | GSK3BMAPK10CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341788-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | EP | claimed |