Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425637 | 0.83 | TSHR (0.44) | TSHRSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL7559624 | 0.82 | MAPT (0.51) | TSHRSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6695927 | 0.82 | MEN1 (0.46) | TSHRSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6425518 | 0.82 | TSHR (0.42) | TSHRSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL28932909 | 0.82 | SMN1; SMN2 (0.42) | TSHRNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9119101 | 0.79 | TSHR (0.45) | TSHRSMN1; SMN2HPGDALDH1A1MAPT | |
| SCHEMBL5105601 | 0.78 | L3MBTL1 (0.41) | TSHRHPGDALDH1A1MAPTLMNA | |
| SCHEMBL8492599 | 0.77 | MAPT (0.52) | TSHRNPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6425417 | 0.77 | TSHR (0.38) | TSHRNPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6425420 | 0.77 | TSHR (0.38) | TSHRNPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |