Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.72 |
| ▸ | CDK4 | P11802 | 16/20 | 0.72 |
| ▸ | GSK3B | P49841 | 15/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.72 |
| ▸ | CCNK | O75909 | 1/20 | 0.70 |
| ▸ | CCNC | P24863 | 1/20 | 0.70 |
| ▸ | CDK8 | P49336 | 1/20 | 0.70 |
| ▸ | CDK9 | P50750 | 1/20 | 0.70 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478725 | 0.89 | CDK2 (0.82) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL6206049 | 0.89 | CDK2 (0.81) | CDK2CDK4GSK3BDYRK1A | |
| SCHEMBL4484286 | 0.84 | CDK2 (1.00) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL4483859 | 0.83 | CDK2 (1.00) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL4483102 | 0.83 | CDK2 (0.81) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL4486038 | 0.83 | CDK2 (0.81) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL19406442 | 0.83 | CDK4 (0.69) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL4473459 | 0.83 | CDK2 (1.00) | CDK2CDK4GSK3BDYRK1ACCNK | |
| Gw805758X SCHEMBL31244858 | 0.83 | CDK2 (1.00) | CDK2CDK4GSK3BDYRK1ACCNK | |
| SCHEMBL4486744 | 0.83 | CDK2 (1.00) | CDK2CDK4GSK3BDYRK1ACCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551842-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |