Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.81 |
| ▸ | GSK3B | P49841 | 14/20 | 0.81 |
| ▸ | CDK4 | P11802 | 14/20 | 0.81 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.81 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazolopyridazine 1 SCHEMBL4489357 | 0.90 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1ASLC2A1 | |
| SCHEMBL6204047 | 0.89 | CDK2 (0.72) | CDK2GSK3BCDK4DYRK1A | |
| Gw801372X SCHEMBL4472952 | 0.83 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1A | |
| SCHEMBL4484286 | 0.81 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1A | |
| SCHEMBL4488333 | 0.81 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1A | |
| SCHEMBL13713471 | 0.81 | DYRK1A (0.75) | CDK2GSK3BCDK4DYRK1ASLC2A1 | |
| SCHEMBL4478725 | 0.80 | CDK2 (0.82) | CDK2GSK3BCDK4DYRK1A | |
| Gw778894X SCHEMBL4464130 | 0.80 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1ASLC2A1 | |
| SCHEMBL4479694 | 0.80 | CDK2 (0.77) | CDK2GSK3BCDK4DYRK1ASLC2A1 | |
| Gw778894X SCHEMBL29636882 | 0.80 | CDK2 (1.00) | CDK2GSK3BCDK4DYRK1ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551842-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |