Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388625 | 0.88 | HRH3 (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL5381743 | 0.85 | HRH3 (0.56) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL3860546 | 0.82 | MCHR1 (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL3860554 | 0.82 | MCHR1 (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL264564 | 0.82 | LTA4H (0.57) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL5255573 | 0.81 | MCHR1 (0.50) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL5381777 | 0.79 | LTA4H (0.54) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL1928086 | 0.78 | HRH3 (0.56) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL3863267 | 0.78 | KDM4E (0.53) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL5389879 | 0.78 | SMN1; SMN2 (0.47) | ALDH1A1MAPTSMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497265-A1 | COMPOUNDS HAVING AFFINITY AT 5HT2C RECEPTOR AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003089409-A1 | COMPOUNDS HAVING AFFINITY AT 5HT2C RECEPTOR AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2003-10-30 | — | — | WO | disclosed |