Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203296 | 0.99 | CRHR1 (0.57) | CRHR1SCN9ARUNX1NR1I2 | |
| SCHEMBL6202563 | 0.99 | CRHR1 (0.57) | CRHR1SCN9ARUNX1NR1I2 | |
| SCHEMBL6203243 | 0.90 | CRHR1 (0.48) | CRHR1SCN9ARUNX1NR1I2GRM7 | |
| SCHEMBL6202901 | 0.89 | CRHR1 (0.47) | CRHR1SCN9ARUNX1NR1I2GRM7 | |
| SCHEMBL6201148 | 0.89 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6204012 | 0.88 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6202775 | 0.88 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6204277 | 0.87 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6203153 | 0.87 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6203641 | 0.86 | CRHR1 (0.56) | CRHR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |