Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055631 | 0.88 | MAPT (0.50) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3049771 | 0.85 | TDP1 (0.46) | SMN1; SMN2MAPTVCAM1CYP19A1ALDH3A1 | |
| SCHEMBL5278989 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3050952 | 0.83 | MAPT (0.46) | SMN1; SMN2MAPTVCAM1CYP19A1ALDH3A1 | |
| SCHEMBL3050970 | 0.81 | MEN1 (0.45) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3045411 | 0.81 | MAPT (0.44) | SMN1; SMN2MAPTVCAM1CYP19A1ALDH3A1 | |
| SCHEMBL5692532 | 0.81 | PGR (0.43) | MAPTKDM4EMEN1KMT2AVCAM1 | |
| SCHEMBL10602642 | 0.80 | MAPT (0.60) | SMN1; SMN2MAPTVCAM1MAPK1CYP3A4 | |
| SCHEMBL3053986 | 0.78 | MAPT (0.50) | MAPTKDM4EMEN1KMT2AVCAM1 | |
| SCHEMBL3058223 | 0.78 | TDP1 (0.40) | SMN1; SMN2MAPTVCAM1CYP19A1ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | Amgen Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003101985-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC. (US) | 2003-12-11 | — | — | WO | disclosed |