Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203042 | 0.84 | TP53 (0.52) | ALDH1A1TSHRHSD17B10TP53HTT | |
| SCHEMBL16950473 | 0.78 | TP53 (0.41) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL30806659 | 0.77 | TP53 (0.47) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL16618296 | 0.77 | TP53 (0.47) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL1125463 | 0.77 | TP53 (0.47) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL17946909 | 0.77 | TP53 (0.47) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL22107986 | 0.77 | TDP1 (0.47) | ALDH1A1TSHRTDP1MEN1KMT2A | |
| SCHEMBL21572137 | 0.77 | PDE2A (0.54) | CYP3A4LMNAMEN1KMT2AKDM4E | |
| SCHEMBL9854302 | 0.76 | TSHR (0.48) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL6204466 | 0.76 | TP53 (0.39) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |