Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204469 | 0.84 | ALDH1A1 (0.40) | TP53LMNAHTTNPSR1MEN1 | |
| SCHEMBL19254214 | 0.79 | LMNA (0.52) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL16212082 | 0.79 | TP53 (0.55) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL9972324 | 0.78 | TP53 (0.46) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL14992635 | 0.77 | TP53 (0.63) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL30869925 | 0.77 | TP53 (0.63) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL13866426 | 0.77 | TP53 (0.63) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL30398975 | 0.77 | TP53 (0.63) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL2295891 | 0.77 | TP53 (0.63) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL6203039 | 0.76 | TP53 (0.52) | TP53LMNAHTTIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |