Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL590012 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL4627799 | 0.85 | CYP4A11 (0.49) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL14428114 | 0.84 | PDGFRB (0.44) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL27696794 | 0.84 | PDGFRB (0.44) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL4627839 | 0.84 | PDGFRB (0.44) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL13634220 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL23507219 | 0.83 | PPARA (0.45) | MAPTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL590781 | 0.82 | TTR (0.47) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL2770959 | 0.81 | HPGD (0.46) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA | |
| SCHEMBL2277745 | 0.81 | PDGFRB (0.46) | SMN1; SMN2MAPTPDGFRBFGFR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |