Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427058 | 0.83 | IDO1 (0.47) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL248466 | 0.83 | IDO1 (0.47) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL6204787 | 0.79 | IDO1 (0.44) | IDO1TDO2ALDH1A1MAPK1PARP1 | |
| SCHEMBL17922061 | 0.79 | IDO1 (0.44) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL4209186 | 0.79 | IDO1 (0.48) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL3711395 | 0.79 | ALDH1A1 (0.44) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL28920974 | 0.79 | IDO1 (0.44) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL3456691 | 0.79 | ALDH1A1 (0.45) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL7755282 | 0.79 | ALDH1A1 (0.45) | IDO1TDO2ALDH1A1GBA1MAPK1 | |
| SCHEMBL3456122 | 0.79 | ALDH1A1 (0.45) | IDO1TDO2ALDH1A1GBA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |