Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427840 | 0.73 | MEN1 (0.71) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL31237204 | 0.72 | MAPK1 (0.65) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL4320562 | 0.72 | MAPK1 (0.65) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL31237623 | 0.72 | MEN1 (0.78) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL4426708 | 0.70 | ALDH1A1 (0.57) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL3023520 | 0.70 | ALDH1A1 (0.64) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL4426684 | 0.69 | MAPK1 (0.61) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL3605267 | 0.69 | CYP19A1 (0.47) | ALDH1A1CYP19A1CYP3A4HTR2AHTR2C | |
| SCHEMBL8549111 | 0.68 | ALDH1A1 (0.72) | MAPK1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL6229682 | 0.68 | HSD17B10 (0.51) | MAPK1HSD17B10ALDH1A1CYP19A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392683-A4 | SUBSTITUTED 4 i H /i -CHROMENES AND ANALOGS AS ACTIVATORS OFGASP ASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2005-10-26 | — | — | EP | claimed |
| EP-1392683-A1 | SUBSTITUTED 4 i H /i -CHROMENES AND ANALOGS AS ACTIVATORS OFGASP ASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2004-03-03 | — | — | EP | claimed |
| WO-2002092594-A1 | SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-11-21 | — | — | WO | claimed |