Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369499 | 0.79 | CYP2C19 (0.44) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6325 | 0.79 | CYP2C19 (0.44) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL29691210 | 0.77 | CYP2C19 (0.46) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL18865623 | 0.77 | CYP2C19 (0.46) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6202860 | 0.77 | ESR1 (0.52) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6204701 | 0.77 | GABRA1 (0.43) | CYP3A4LMNACYP1A2POLBHPGD | |
| SCHEMBL6203755 | 0.77 | CA1 (0.52) | ALDH1A1IDO1TDO2HTTKDM4E | |
| SCHEMBL6205005 | 0.76 | CYP2C19 (0.45) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL10992504 | 0.76 | CYP2C19 (0.41) | CYP2C19CYP2C9ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6204869 | 0.76 | MEN1 (0.41) | CYP2C9ALDH1A1CYP3A4IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |