Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29857877 | 0.79 | NPC1 (0.66) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL26916989 | 0.79 | NPC1 (0.66) | NPC1RAB9AKMT2AMEN1HTT | |
| SCHEMBL6079292 | 0.77 | MAPT (0.64) | RAB9AKMT2AMEN1CYP19A1SMN1; SMN2 | |
| SCHEMBL6079865 | 0.74 | MAPT (0.45) | RAB9AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL28695929 | 0.74 | HSD17B10 (0.58) | KMT2AMEN1SMN1; SMN2HTTMAPT | |
| SCHEMBL8367532 | 0.74 | MEN1 (0.69) | NPC1KMT2AMEN1CYP19A1ALDH1A1 | |
| SCHEMBL27097026 | 0.73 | KMT2A (0.53) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8566987 | 0.72 | LMNA (0.47) | NPC1RAB9AKMT2AMEN1CYP19A1 | |
| SCHEMBL488932 | 0.72 | NPC1 (0.62) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6204688 | 0.71 | MAPT (0.57) | RAB9AKMT2AMEN1CYP19A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |