Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12837818 | 0.80 | IDO1 (0.44) | IDO1TDO2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL30608097 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1SLC6A2 | |
| SCHEMBL511201 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1SLC6A2 | |
| SCHEMBL6205041 | 0.78 | IDO1 (0.46) | IDO1TDO2ALDH1A1MAPK1MAPT | |
| SCHEMBL6204449 | 0.78 | ADRB1 (0.53) | ALDH1A1CYP3A4SLC6A3 | |
| SCHEMBL3319428 | 0.78 | IDO1 (0.46) | IDO1TDO2ALDH1A1MAPK1SLC6A2 | |
| SCHEMBL28582936 | 0.78 | CYP3A4 (0.47) | ALDH1A1CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL6201854 | 0.78 | AOC3 (0.49) | ALDH1A1MAPK1 | |
| SCHEMBL13140614 | 0.78 | HDAC4 (0.47) | ALDH1A1CYP3A4MAPT | |
| SCHEMBL20306986 | 0.77 | CYP2A6 (0.42) | ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |