Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16942017 | 1.00 | ADH1A (0.40) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL29723333 | 0.91 | BACE1 (0.41) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL18086012 | 0.91 | BACE1 (0.41) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL16942012 | 0.85 | ADH1A (0.41) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL21297107 | 0.83 | ADH1A (0.39) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL19607324 | 0.82 | EPHX2 (0.39) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL16847519 | 0.81 | ADH1A (0.48) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL16933070 | 0.81 | BACE1 (0.37) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL18064565 | 0.80 | ADH1A (0.38) | ADH1AKITFLT1FLT4KDR | |
| SCHEMBL18064566 | 0.80 | ADH1A (0.38) | ADH1AKITFLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |