SCHEMBL6205149

SCHEMBL6205149

COC(O)c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.44
AOC3 Q16853 2/20 0.44
SLC6A4 P31645 1/20 0.44
BRD4 O60885 1/20 0.42
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
IDO1 P14902 2/20 0.41
TDO2 P48775 2/20 0.41
TSHR P16473 2/20 0.41
MAPK1 P28482 2/20 0.41
HIF1A Q16665 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
GAA P10253 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
CYP2A6 P11509 1/20 0.38
HDAC4 P56524 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9979794 0.87 AOC3 (0.34) AOC3TSHRGAA
SCHEMBL13283559 0.83 TYR (0.41) SMN1; SMN2IDO1MAPK1HIF1AGAA
SCHEMBL21769395 0.78 ESR1 (0.50) LMNASMN1; SMN2TSHRHIF1ATDP1
SCHEMBL17124666 0.78 TSHR (0.36) AOC3TSHRKMT2A
SCHEMBL6203868 0.78 CHRNA7 (0.41) LMNATSHRTDP1MEN1KMT2A
SCHEMBL6205146 0.76 CNR2 (0.39) AOC3SMN1; SMN2IDO1TDO2TSHR
SCHEMBL6202340 0.76 CYP1A2 (0.42) SLC6A4LMNAMAPK1GAAMEN1
SCHEMBL2645634 0.76 BLM (0.32) TSHRGAAKMT2A
SCHEMBL20960412 0.76 TDP1 (0.42) TSHRMAPK1HIF1ATDP1GAA
SCHEMBL10186917 0.76 IDO1 (0.31) IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112912081-A Substituted 2, 4-diamino-quinolines as novel agents for fibrosis, autophagy and cathepsin B (CTSB), L (CTSL) and D (CTSD) related diseases 基因科学医药公司 2021-06-04 CN disclosed
EP-1506175-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-16 EP disclosed
WO-2003097609-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2003-11-27 WO disclosed