Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641737 | 0.85 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL3570697 | 0.83 | TDP1 (0.50) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL3841885 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL1067609 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL16803358 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL715298 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL14363082 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL10902775 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL961310 | 0.81 | TSHR (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL1826328 | 0.81 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1738798-A | Indole derivatives as somatostatin agonists or antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |
| EP-0382687-B1 | Benzofused-N-containing heterocycle derivatives | BOEHRINGER INGELHEIM ITALIA (IT) | 1995-12-27 | — | — | EP | disclosed |
| US-5106851-A | Respiratory system disorders | ISTITUTO DE ANGELI S.P.A. (IT) | 1992-04-21 | — | — | US | disclosed |
| EP-0382687-A2 | Benzofused-N-containing heterocycle derivatives | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1990-08-16 | — | — | EP | disclosed |