Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843755 | 0.86 | TDP1 (0.60) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL14641737 | 0.85 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL14363082 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL6205360 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL16803358 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL715298 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL10902775 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL3841885 | 0.81 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL961310 | 0.81 | TSHR (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL5237985 | 0.81 | ALDH1A1 (0.50) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232104-A | Method for preparing indazole carboxylic acid | 青岛恒宁生物科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-111825654-A | Phenylmethylene piperidine derivatives, preparation method, intermediates and uses thereof | 北京酷瓴生物技术有限公司 | 2020-10-27 | — | — | CN | disclosed |
| WO-2020211836-A1 | BENZENE PIPERIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF | 北京酷瓴生物技术有限公司 | 2020-10-22 | — | — | WO | disclosed |
| WO-2020211836-A1 | BENZENE PIPERIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF | 北京酷瓴生物技术有限公司 | 2020-10-22 | — | — | WO | disclosed |
| CN-106061938-B | The manufacturing method of 2- (halogenated methyl) -3- methyl nitrobenzene | 住友化学株式会社 | 2019-04-12 | — | — | CN | disclosed |
| US-9815768-B2 | Method for producing 2-(halogenomethyl)-3-methylnitrobenzene | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-11-14 | — | — | US | disclosed |
| US-20160332956-A1 | METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| CN-106061938-A | Method for producing 2-(halogenomethyl)-3-methylnitrobenzene | 住友化学株式会社 | 2016-10-26 | — | — | CN | disclosed |
| US-8987256-B2 | Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |
| WO-2005060456-A2 | METHOD FOR TREATING ADAMTS-5-ASSOCIATE DISEASE | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061459-A1 | BIARYL SULFONAMIDES AND METHODS FOR USING SAME | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050130973-A1 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2005-06-16 | — | — | US | disclosed |
| CN-1206219-C | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2005-06-15 | — | — | CN | disclosed |
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |
| EP-0021338-B1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-12 | — | — | EP | disclosed |
| US-4256748-A | INOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| EP-0021338-A1 | Quinazoline derivatives and pharmaceutical preparations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130973-A1 | Biaryl sulfonamides and methods for using same | STS, MMP3, AADAC | TDP1 2062/4885TSHR 4078/4885SMN1; SMN2 3220/4885 |
| US-20160332956-A1 | METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE | CYP1B1, DNMT1, DNMT3A | TDP1 2652/4885TSHR 1157/4885SMN1; SMN2 3141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.