Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CFTR | P13569 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204124 | 0.88 | POLB (0.53) | POLBCFTRLMNAL3MBTL1 | |
| SCHEMBL6205607 | 0.88 | POLB (0.75) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6205837 | 0.84 | POLB (0.78) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6205243 | 0.82 | GABRP (0.68) | POLBMEN1KMT2ACFTRLMNA | |
| SCHEMBL6204972 | 0.82 | POLB (1.00) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6205212 | 0.80 | POLB (0.80) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6204810 | 0.79 | POLB (0.88) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6161505 | 0.79 | POLB (0.47) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL6163159 | 0.79 | POLB (0.47) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL30492092 | 0.77 | CFTR (0.73) | POLBMEN1KMT2ATP53CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |