Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478903 | 0.80 | IDO1 (0.45) | IDO1PPARGPPARATAAR1ALDH1A1 | |
| SCHEMBL6205489 | 0.78 | IDO1 (0.44) | IDO1PPARGPPARATAAR1ALDH1A1 | |
| SCHEMBL6205188 | 0.78 | LMNA (0.43) | PPARGPPARATAAR1ALDH1A1CYP3A4 | |
| SCHEMBL15319327 | 0.78 | TAAR1 (0.44) | IDO1PPARGPPARATAAR1CYP2C19 | |
| SCHEMBL29679614 | 0.78 | TAAR1 (0.44) | IDO1PPARGPPARATAAR1CYP2C19 | |
| SCHEMBL14997308 | 0.78 | TAAR1 (0.44) | IDO1PPARGPPARATAAR1CYP2C19 | |
| SCHEMBL625240 | 0.78 | TAAR1 (0.44) | IDO1PPARGPPARATAAR1CYP2C19 | |
| SCHEMBL10701084 | 0.77 | TAAR1 (0.46) | IDO1PPARGPPARATAAR1ALDH1A1 | |
| SCHEMBL24272357 | 0.77 | IDO1 (0.42) | IDO1TAAR1ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL6206376 | 0.77 | IDO1 (0.48) | IDO1TAAR1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |