Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 6/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9069984 | 0.89 | MAOB (0.48) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL6224544 | 0.84 | APP (0.45) | APPCYP2C19KMO | |
| SCHEMBL9227701 | 0.81 | HIF1A (0.47) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL6224211 | 0.81 | APP (0.45) | MEN1KMT2AAPPCYP2C19CYP3A4 | |
| SCHEMBL6207370 | 0.80 | BCL2L1 (0.54) | MEN1LMNAKMT2AHSD17B10 | |
| SCHEMBL11101459 | 0.80 | ESR1 (0.51) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL6205277 | 0.79 | MAPT (0.44) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL12152596 | 0.79 | BACE1 (0.47) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL10600475 | 0.78 | TTR (0.62) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL9229790 | 0.78 | KMT2A (0.42) | TTRKDM4EMEN1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |