Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 15/20 | 0.47 |
| ▸ | AURKA | O14965 | 14/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205640 | 0.82 | TSHR (0.43) | RPS6KB1AURKAAURKBCCNB2CDK1 | |
| SCHEMBL4913008 | 0.82 | AURKA (0.47) | RPS6KB1AURKAAURKBCCNB2CDK1 | |
| SCHEMBL3445112 | 0.80 | CDK2 (0.43) | RPS6KB1AURKAAURKBCCNB2CDK1 | |
| SCHEMBL6205357 | 0.80 | EGFR (0.54) | RPS6KB1AURKAAURKBCCNB2CDK1 | |
| SCHEMBL3444022 | 0.79 | CDK2 (0.50) | RPS6KB1AURKAAURKBCCNB2CDK1 | |
| SCHEMBL3446179 | 0.77 | CDK2 (0.48) | CCNB2CDK1CCNB1CCNB3CDK7 | |
| SCHEMBL3444866 | 0.76 | CDK1 (0.48) | AURKACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3444383 | 0.76 | CDK2 (0.51) | AURKACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3444807 | 0.76 | CDK2 (0.49) | AURKBCDK1CCNB1PIM1GSK3B | |
| SCHEMBL4913014 | 0.74 | LMNA (0.65) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |